I am getting the following when trying to access Webmail.  I really dont know what step to do next to get this working.

Failed to access IIS metabase.
Description: An unhandled exception occurred during the execution of the current web request. Please review the stack trace for more information about the error and where it originated in the code.

Exception Details: System.Web.Hosting.HostingEnvironmentException: Failed to access IIS metabase.

The process account used to run ASP.NET must have read access to the IIS metabase (e.g. IIS://servername/W3SVC). For information on modifying metabase permissions, please see http://support.microsoft.com/?kbid=267904.

Source Error:

An unhandled exception was generated during the execution of the current web request. Information regarding the origin and location of the exception can be identified using the exception stack trace below. 

Stack Trace:

[HostingEnvironmentException: Failed to access IIS metabase.]
   System.Web.Configuration.MetabaseServerConfig.MapPathCaching(String siteID, VirtualPath path) +3492170
   System.Web.Configuration.MetabaseServerConfig.System.Web.Configuration.IConfigMapPath.MapPath(String siteID, VirtualPath vpath) +9
   System.Web.Hosting.HostingEnvironment.MapPathActual(VirtualPath virtualPath, Boolean permitNull) +163
   System.Web.CachedPathData.GetConfigPathData(String configPath) +382
   System.Web.CachedPathData.GetConfigPathData(String configPath) +243
   System.Web.CachedPathData.GetApplicationPathData() +68
   System.Web.CachedPathData.GetVirtualPathData(VirtualPath virtualPath, Boolean permitPathsOutsideApp) +3385679
   System.Web.Configuration.RuntimeConfig.GetLKGRuntimeConfig(VirtualPath path) +189

Application Pool will be found in IIS Manager:

Unless you added some pools like I did, there should be one there called DefaultAppPool. Select it, right click and then select the Identity Tab.  Ensure that pre-defined is selected and that it shows Network Service as the Account to use for that pool.

The next step is to check the file permissions of your web site. You need to navigate to the root folder of your web site, for example: c:\inetpub\wwwroot\.  Select the folder, right click the folder and select Properties, then select the Security Tab. 

You want to ensure that the wwwroot folder has at a minimum these permissions:

These services should be there:

Network Service

Interactive

System (all the above should have Full Control)

 Network (List Folders only).

If you do not see this type of Tab, What Operating System are you using and what file system do you have installed (FAT, FAT32, NTFS)?

After reading the above post from mtosborne I decided to take the following steps:

1. I uninstalled Webmail

2. I uninstalled IIS

3. I uninstalled the .NET Framework

4. Rebooted. (note your mail server will not work cause .NET has been removed)

5. I installed IIS

6. I installed the .NET Framework

7. Rebooted

8. I installed the Webmail interface

9. It works like a champ.

Thanks for everyones help.